ڻҽ

HOME > Ұ > ҽ > ڻҽ > мȰ
Խ

ó Ȱ ȿ, Űȸ(INS) 2004 10ȣ

¥2006.08.15 ȸ80,267

ڻѹ溴 ó (ӡ) ̱ ĶϾ δ(UCI : University of California, Irvine) Ű м Ȱȭ ȿ ߴ. Űȸ(INS: International journal of Neuroscience) 10ȣ(2004) Ǿ. ڻѹ溴 ȣϴ ȯ 100 óϿ ѷ 2001 4 ĶϾ δ Ű Ȱȭ ȿɿ м ûϿ.

INS ӻ ‘ ջ ġ ȿ (The herbal prescription Youkongdan modulates rodent memory, ischemic damage and cortical mRNA gene expression)’.

Űȸ

ϸ ‘ ջ 迡 ȸ ջ ϴ Ű ȣȿ پ Ÿ, Ȱȭ κп ȿ ȴ’ ̴.

̹ δ H Ÿ (Edward H. Sharman), Űغ â ڻ ߴ. ĶϾ δ ü ī, ֱ ΰ ƺ ٱ⼼ ȭ Ȳ켮 ǰ ŭ м ް ִ.

ѹ ȿɿ м , ‘’ ܼ õ ƴ ‘ѹ ó’ ִ ܱ ǰ, м ʴ ſ 幰. ׷Ƿ ̹ ڻѹ溴 ø й ѹ ó ȿɿ üȭ ۵ ĥ ȴ.

 

 

, ȸ ȿ
ȸ ι ο ȿ ־. ̴ 㸦 ̿ 𸮽(Moriss water maze) ̷ ൿ ƴ. ù 迡 , (), 7ϰ (񱳱) ԵǾ. Ǵ밡 ġ 𸮽 ߹̷ο 5ϰ Ǵ븦 ãư Ʒ ޾Ҵ. Ǵ븦 ãư ϴ н Ÿ. 񱳱 ̷ ְ , ̷ο Ǵ븦 6 ° Ǵ밡 ִ ڸ ãưµ ɸ ð 10.4, 20.8, 񱳱 10.9ʰ ɷ, ȿ ߴ.

 

()   ߹̷ , ()    ߹̷ , ()    7     ߹̷

 

() ߹̷
() ߹̷

() 7ϰ ߹̷

 

° 迡 , Ű ı (), 7ϰ (񱳱) ԵǾ. Ǵ밡 ִ ڸ ãư Ƚ ڸ ӹ ð ߴ. 5.2±13.6ȸ, 3.28±7.46ȸ, 񱳱 4.7±12.9ȸ Ÿ 񱳱 89.7% ̸ ȸ Ÿ. ̴ ܱ(Ǹ) ٿ ȸϴµ ȿ ִٴ ǹѴ.

 

 ,   Ű ı (),  7ϰ   (񱳱) ԵǾ.  Ǵ밡 ִ ڸ ãư Ƚ  ڸ ӹ ð  ߴ.    5.213.6ȸ,  3.287.46ȸ, 񱳱 4.712.9ȸ Ÿ 񱳱   89.7% ̸  ȸ   Ÿ ׷

 

㰡 scopolamine ֻ 㺸 Ǵ뿡 Ͽ. 6° 12ð Ŀ Ǵ뿡 ϴ ð ˼ ־.

 

 ,   Ű ı (),  7ϰ   (񱳱) Ե 迡  5.213.6 ȸε  scopolamine ֻ ( ) 3.287.46 ȸ ϵǾ,   4.712.9 ȸ   ׷

 

ȸ⿡ Ǵ밡 ־ ġ ȸ Ÿ. 5.2±13.6 ȸε scopolamine ֻ ( ) 3.28±7.46 ȸ ϵǾ, 4.7±12.9 ȸ Ÿ.

 

, Ű溸ȣȿ ջ

ƿ﷯ Ű溸ȣȿ 㿡 н ϴ ظ ü Ű漼(Ƕ̴ ) κ · ִ мƴ. , ջ ϴ Ű漼 DZ ̾ϰ Ÿ ѹ ó ջǴ Ű漼 ȣϿ ջ ߴ. ̴ Ʈ ջ µ ȿ ǹѴ.

 

 Ű溸ȣȿ  ,  ̹. (׸ A B) ׷쿡 CA1 ü  κ Ű  ¸ Ѵ. (׸ C)   ü ϰ  ظ CA1κ Ű漼 ջ  ޾Ҵ. (׸ D) 簡  Ű漼̸ ۶̿ý   ׸̴. (׸ E F)    ظ CA1 ü ջ    ־.

 

׷쿡 CA1 ü κ Ű ¸ Ѵ(׸ B).
ü ϰ ظ CA1κ Ű漼 ջ ޾Ҵ(׸ C). ׸ D 簡 Ű漼̸ ۶̿ý ׸̴. ظ CA1 ü ջ ־(׸ E F). ü ȭ 㳪 㿡 Ƿ Ű溸ȣȿ üϿ ƴ ־.

 

 ⹰ ȿ ׷ -  3027.4 cells/mm2  ݸ, Ŀ   381.7 cells/mm2  ս Դ.    ⹰ 100mg/kg 豺 2753.6 cells/mm2  Ͽ  ȿ ־(p<0.05).

 

⹰ ȿ 302±7.4 cells/mm2 ݸ, Ŀ 38±1.7 cells/mm2 ս Դ. ⹰ 100mg/kg 豺 275±3.6 cells/mm2 Ͽ ȿ ־(p<0.05).

 

Ȱȭ Ŀ, Egr1 ܹ

߿ ̹ ũĨ ̿ mRNA , ӿ Egr1̶ ܹ ũ ϴ ߰ߵƴٴ ̴. ̴ Ȱȭ , Egr1 ܹ Ǵ ȸŰ, ̰ ҵ ߿ ġ ˷ ִ.

˻
̵
˻
ó 1 2 3 4 5 6 7

Ȼڻѹ溴  ȯ

  • Ȼڻѹ溴 㸮ȯ
  • Ȼڻѹ溴 ô߰
  • Ȼڻѹ溴 ȯ
  • Ȼڻѹ溴 ȯ
  • Ȼڻѹ溴 ȯ
  • Ȼڻѹ溴 ȯ
  • Ȼڻѹ溴
  • Ȼڻѹ溴 ߳
  • Ȼڻѹ溴 ȸŰ渶