Źٷξħ(Źٷ3), پ ȿ Ź |
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¥2018.04.16 | ȸ19,636 |
Źٷξħ(Źٷ3), پ ȿ Ź
õ ּ Źٷξħ(Źٷ3) پ ڸ ÿ Ѵٴ ǥƽϴ. SCI м Mediators of Inflammation(IF=3.232) ֽȣ(2018 4ȣ) ƽϴ.
Ǹ 顯̶ Ҹ õ(Harpagophytum procumbens) , , ȭ ȿ ־ ġῡ ̴ Դϴ. ڻô߰( ) ȭ? ȿ Ű ̱ õ Ͽ Źٷ3ħ ߽ϴ.
Źٷ3ħ ڻѹ溴 پ ȯ ٰݰ ȯ ġϴ ̰ ִµ. ̹ Źٷ3 Ȯ , ȿ õٺ پٴ ƽϴ.
õ Ͽ Źٷ3 ϸİ̵(harpagoside)κ ϸ̵(harpagide) óͻ(cinnamic acid) иϿ ߵƽϴ. õٰ ϸİ̵, ϸ̵, óͻ ȿ ̹ ȿ ؼ Ÿ Ȯϰ ʾҴµ.
̿ Źٷ3 ȿ ˾ƺ ļ(LPS ó) ̿ Ȱ(NO?nitric oxide) ܹ iNOS(inducible nitric oxide synthase), COX-2 ߽ϴ.
[ǥ 1] Źٷ3 õ(H.procumbens) Ȱ(NO) ȿ پ Ÿ. Ȱ ȿ پٴ ȿ ũٴ Ѵ.
Źٷ3 õٿ Ȱ ȿ ϴ. 200?400?800?1,000g/ML Źٷ3 õٺ پ ȭ ȿ Ȱ ȿ ҽϴ. ̴ Źٷ3 ȿ ´ٴ մϴ.
Źٷ3 ߿ ϴ COX2 iNOS , TNF-alpha IL-1beta īε ϴ Ÿϴ.
[ǥ 2] NF-kappaB ȭ Űϴ ٽ ڴ. Źٷ3ħ Ȱ ȿ Ͽ ȿ Ÿ.
ó õ Ͽ ߵ Źٷ3 õٿ ȿ ϴ. ٸ ̷ Ư Ե ؼ ߰ ʿϴٰ ϴ.
ֱ MRI ܿ ʴ ȭ ȭ, ȭ ӻ ߱ ִ ϳ ǰ ֽϴ. ؼ ʰ ϱ ٴ ǹε. ̹ Źٷ3 ȿ Ȯ ̴ Źٷ3ħ ٰݰ ȯ ־ ٺġᰡ ִٴ ɼ ûմϴ.
ڻô߰ ̹ õ Ͽ Źٷ3 ӻ ȿ Ÿ Ըߴٴ ǰ ִ١ ̹ Źٷ3 Ȱ , COX2 ν ȿ Ÿ ƴ. ̷ ν Źٷ3 ġṰ ȴ١ ߽ϴ.
[] Mediators of Inflammation ֽȣ(4ȣ) ش The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages |